The essentials at a glance

HCV is a virus that affects the liver. Some infections clear spontaneously, but many become chronic.

What is it?

HCV is a virus that affects the liver. Some infections clear spontaneously, but many become chronic.

How is it transmitted?

Primarily through blood. Sexual transmission is possible, especially with blood contact, mucosal injury and certain sexual practices.

How is it not transmitted?

It is not transmitted through food, water, hugs or ordinary kissing.

What happens after exposure?

Infection often goes unnoticed. Blood exposure calls for medical assessment and a testing plan; there is no established drug PEP for HCV.

Incubation period

When symptoms occur, they can start from about two weeks to six months after exposure.

Window period: when should I test?

HCV RNA can be detected after approximately 1–2 weeks, while antibodies usually appear after 8–11 weeks. These are guides; recent exposure may require RNA testing despite negative antibodies.

What are the symptoms?

Fatigue, nausea, dark urine and jaundice. Chronic infection often causes no specific symptoms.

Can there be no symptoms?

Yes, even when liver damage is present. Symptoms are not a reliable way to check.

Which parts of the body can be affected?

Mainly the liver, with possible effects elsewhere. Diagnosis uses blood testing.

How is it tested?

Anti-HCV antibodies first, followed by HCV RNA for current infection if reactive. Recent exposure may call for a different approach.

What sample is needed?

Blood for antibodies and/or RNA. Liver health and other medical factors are also assessed before treatment.

What does a positive result mean?

Positive antibodies indicate exposure to the virus, but not necessarily current infection. Detectable RNA establishes current infection.

How is it treated?

Direct-acting antiviral medicines cure most people. The duration and choice depend on the individual clinical context.

Can I acquire it again?

Yes. Successful treatment does not create protective immunity; antibodies can remain positive, so RNA is used to look for a new infection.

What should partners know?

Discuss with a clinician which partners and contacts should be tested. Avoid sharing items that may have blood on them.

How can I reduce the risk?

Do not share needles or equipment. Condoms, lubricant and barriers reduce injury and blood contact during sex. There is no HCV vaccine.

When should I seek medical care?

Seek medical care after blood exposure or for jaundice. Confusion or bleeding require emergency care.

What should I do now?

Clarify whether you have only an antibody result or an RNA result too. Current infection should lead to treatment referral, rather than waiting for symptoms.

I have been cured. Why are antibodies still positive?

Antibodies are a trace of the immune response. RNA testing shows whether the virus is present now; antibodies do not demonstrate treatment failure.

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What can I do now?

The right test depends on the contact, the sample site and the time since exposure.

Help me choose a test

Testing at CheckPoint

These related services are listed in our current catalogue. This is not a recommendation to take every test: the appropriate method and sample depend on the exposure, symptoms and clinical assessment.

Plan your visit or ask about the right sample

Sources and review

CDC: HCV diagnosis

WHO: hepatitis C

Last updated: 11/09/2026